On 24 February 2006, Science published the Report “Molecular linkage between the kinase ATM and NF-κB signaling in response to genotoxic stimuli” by Z.-H. Wu et al. (1). Concerns about Figs. 4E and 4F and fig. S2A were posted to PubPeer in 2020 (2). Because of the age of the paper, we no longer had original files to examine. We have now learned that relevant institutions have completed investigations and have concluded that there was figure manipulation. We are contacting the institutions to obtain further clarification but in the meantime are notifying readers of our concern about the paper’s data integrity.